Benchmarking state-of-the-art CCC tools.

Acknowledging the vast diversity of CCC tools, we focused on algorithms integrating both spatially resolved transcriptomics and intracellular information

First Published: Mar 14, 2025

Last updated: mai 14, 2025

Bastien CHASSAGNOL |
Lecturer & Professional Researcher
LPSM

Marie-Pier Scott |
Lecturer & Professional Researcher
Laval University

Slides & source code available on GitHub

Talks’ Layout

Types and applications of cell–cell tools. 👋
CCC tools pipeline 🕘
Review of CCC tools ⬇️

Types of Cell-Cell Communication

Cell-cell Categories

Classes of cell-cell communications cover:

Autocrine signalling: induce a cellular response within the same cell.
Paracrine signalling: diffusion of signalling, secreted molecules in the external medium.
Juxtacrine signalling: contact-dependant, through gap junctions or membrane nanotubes.
Endocrine signalling: long-range intercellular communication enabled by blood-circulating hormones.

Review of CCC tools

Main categories of cell-cell tools

Phylogenetic tree of cell-cell tools

Phylogenetic tree of computational tools for inferring cell–cell interactions, from (armingol2024nrg?). Tools published as a preprint are marked with an asterisk. — Phylogenetic tree of computational tools for inferring cell–cell interactions, from (**armingol2024nrg?**). Tools published as a **preprint** are marked with an asterisk.

Conclusion

Take-Aways:

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Bibliographic References

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